› 8fkc

X-ray diffraction
1.42Å resolution

Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR33544

Released:
DOI: 10.2210/pdb8fkc/pdb
PDB entry 8fkc coloured by chain, front view.
PDB entry 8fkc coloured by chain, side view.
PDB entry 8fkc coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: MacTavish BS, Kojetin DJ

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130926 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Nuclear receptor corepressor 1 Chain: D
Molecule details ›
Chain: D
Length: 23 amino acids
Theoretical weight: 2.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75376 (Residues: 2256-2278; Coverage: 1%)
Gene names: KIAA1047, NCOR1

Ligands and Environments

2 bound ligands:
Ligand Y5F 1 x Y5F
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P41212
Unit cell:
a: 62.054Å b: 62.054Å c: 160.719Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.198
Expression system: Escherichia coli

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