› 8fkm

Solution NMR

Human Atg3 with deletions of residues 1 to 25 and 90 to 190

Released:
DOI: 10.2210/pdb8fkm/pdb
PDB entry 8fkm coloured by chain, ensemble of 10 models, front view.
PDB entry 8fkm coloured by chain, ensemble of 10 models, side view.
PDB entry 8fkm coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy.
Ye Y, Tyndall ER, Bui V, Bewley MC, Wang G, Hong X, Shen Y, Flanagan JM, Wang HG, Tian F
OpenAccess logo Nat Commun 14 5503 (2023)
PMID: 37679347

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-228862 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin-like-conjugating enzyme ATG3 Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 22.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NT62 (Residues: 25-314; Coverage: 60%)
Gene names: APG3, APG3L, ATG3
Sequence domains: Autophagocytosis associated protein, active-site domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure.
Ye et al. (2024)
2 more