› 8fll

X-ray diffraction
1.5Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase BTK Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 31.79 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q06187 (Residues: 389-659; Coverage: 41%)
Gene names: AGMX1, ATK, BPK, BTK
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

4 bound ligands:
Ligand Y7W 1 x Y7W
Ligand SO4 1 x SO4
Ligand GOL 2 x GOL
Ligand BTB 1 x BTB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 41.482Å b: 67.269Å c: 90.383Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.202
Expression system: Trichoplusia ni

Quick links

Citations

7 review citations

Pirtobrutinib: First Approval.
Keam SJ. (2023)
6 more

3 mentions without citation

Resisting the Resistance: Navigating BTK Mutations in Chronic Lymphocytic Leukemia (CLL).
Chirino et al. (2023)
2 more