› 8fmu

X-ray diffraction
2.03Å resolution

Crystal structure of human Brachyury G177D variant in complex with SJF-4601

Released:
DOI: 10.2210/pdb8fmu/pdb
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PDB entry 8fmu coloured by chain, front view.
PDB entry 8fmu coloured by chain, side view.
PDB entry 8fmu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury.
Chase DH, Bebenek AM, Nie P, Jaime-Figueroa S, Butrin A, Castro DA, Hines J, Linhares BM, Crews CM
Angew Chem Int Ed Engl 63 e202316496 (2024)
PMID: 38348945

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-box transcription factor T Chains: A, B
Molecule details ›
Chains: A, B
Length: 192 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15178 (Residues: 41-224; Coverage: 42%)
Gene names: T, TBXT
Sequence domains: T-box

Ligands and Environments

1 bound ligand:
Ligand Y3T 2 x Y3T
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 58.892Å b: 70.294Å c: 81.874Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.2 0.266
Expression system: Escherichia coli

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