› 8fo4

X-ray diffraction
2Å resolution

Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 6-methyl-2-(2-((1E,2E)-3-(2-nitrophenyl)allylidene)hydrazineyl)pyrimidin-4-ol

Released:
DOI: 10.2210/pdb8fo4/pdb
PDB entry 8fo4 coloured by chain, front view.
PDB entry 8fo4 coloured by chain, side view.
PDB entry 8fo4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity
Yan NL, Wilson IA, Kelly JW
Isr. J. Chem. (2023)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233740 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
H9 immunoglobulin light chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 216 amino acids
Theoretical weight: 22.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand Y4Q 2 x Y4Q
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P1
Unit cell:
a: 45.495Å b: 63.19Å c: 86.978Å
α: 84.76° β: 87.7° γ: 81.18°
R-values:
R R work R free
0.188 0.186 0.238
Expression system: Escherichia coli

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