PDB 8foi structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

extracellular ligand-gated monoatomic ion channel activity

Biological process:

monoatomic ion transmembrane transport

Cellular component:

membrane

Structure analysis Details

Assembly composition:

hetero nonamer (preferred)

Assembly name:

GABA-A receptor, alpha1-beta2-gamma2 and antibody (preferred)

PDBe Complex ID:

PDB-CPX-279864 (preferred)

Entry contents:

5 distinct polypeptide molecules

Macromolecules (8 distinct):

Gamma-aminobutyric acid receptor subunit alpha-1 Chains: A, C

Molecule details ›

Chains: A, C
Length: 455 amino acids
Theoretical weight: 51.82 KDa
Source organism: Mus musculus
UniProt:

Canonical: P62812 (Residues: 1-455; Coverage: 100%)

Gene names: Gabra-1, Gabra1
Sequence domains:

Gamma-aminobutyric acid receptor subunit beta-2 Chains: B, E

Molecule details ›

Chains: B, E
Length: 512 amino acids
Theoretical weight: 59.27 KDa
Source organism: Mus musculus
UniProt:

Canonical: P63137 (Residues: 1-512; Coverage: 100%)

Gene names: Gabrb-2, Gabrb2
Sequence domains:

Gamma-aminobutyric acid receptor subunit gamma-2 Chain: D

Molecule details ›

Chain: D
Length: 474 amino acids
Theoretical weight: 55.16 KDa
Source organism: Mus musculus
UniProt:

Canonical: P22723 (Residues: 1-474; Coverage: 100%)

Gene name: Gabrg2
Sequence domains:

Heavy Chain of 8E3 Fab Chains: H, J

Molecule details ›

Chains: H, J
Length: 223 amino acids
Theoretical weight: 24.16 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda

Light Chain of 8E3-Fab Chains: K, L

Molecule details ›

Chains: K, L
Length: 213 amino acids
Theoretical weight: 23.62 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda