› 8fp9

Electron Microscopy
2.44Å resolution

GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg)

Released:
DOI: 10.2210/pdb8fp9/pdb
PDB entry 8fp9 coloured by chain, front view.
PDB entry 8fp9 coloured by chain, side view.
PDB entry 8fp9 coloured by chain, top view.
Source organisms:
Primary publication:
The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport.
Nakagawa T, Wang XT, Miguez-Cabello FJ, Bowie D
Nat Struct Mol Biol (2024)
PMID: 38409505
Related structures: EMD-29360

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240471 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 889 amino acids
Theoretical weight: 99.56 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 1-868, 869-883; Coverage: 100%)
  • Best match: P19491-2 (Residues: 1-868, 869-883)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Voltage-dependent calcium channel gamma-2 subunit Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 336 amino acids
Theoretical weight: 37.11 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: O88602 (Residues: 1-323; Coverage: 100%)
Gene names: Cacng2, Stg
Sequence domains: PMP-22/EMP/MP20/Claudin family

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.44Å
Relevant EMDB volumes: EMD-29360
Expression system: Homo sapiens

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