› 8fqa

Electron Microscopy
3.35Å resolution

LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110)

Released:
DOI: 10.2210/pdb8fqa/pdb
PDB entry 8fqa coloured by chain, front view.
PDB entry 8fqa coloured by chain, side view.
PDB entry 8fqa coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport.
Nakagawa T, Wang XT, Miguez-Cabello FJ, Bowie D
Nat Struct Mol Biol (2024)
PMID: 38409505
Related structures: EMD-29381

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 889 amino acids
Theoretical weight: 99.56 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 1-868, 869-883; Coverage: 100%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand GLU 4 x GLU
Ligand CYZ 4 x CYZ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.35Å
Relevant EMDB volumes: EMD-29381
Expression system: Homo sapiens

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