› 8fth

Electron Microscopy
3.17Å resolution

Chaetomium thermophilum SETX - NPPC internal deletion

Released:
DOI: 10.2210/pdb8fth/pdb
PDB entry 8fth coloured by chain, front view.
PDB entry 8fth coloured by chain, side view.
PDB entry 8fth coloured by chain, top view.
Source organism: Thermochaetoides thermophila DSM 1495
Primary publication:
Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2.
Appel CD, Bermek O, Dandey VP, Wood M, Viverette E, Williams JG, Bouvette J, Riccio AA, Krahn JM, Borgnia MJ, Williams RS
Mol Cell (2023)
PMID: 37832548
Related structures: EMD-29426

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-232680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5'-3' RNA helicase-like protein Chain: A
Molecule details ›
Chain: A
Length: 1688 amino acids
Theoretical weight: 190.93 KDa
Source organism: Thermochaetoides thermophila DSM 1495
Expression system: Homo sapiens
UniProt:
  • Canonical: G0S163 (Residues: 1-903, 1090-1858; Coverage: 84%)
Gene name: CTHT_0012480
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.17Å
Relevant EMDB volumes: EMD-29426
Expression system: Homo sapiens

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