8fvj

Electron Microscopy
3.54Å resolution

Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-228095 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Core-binding factor subunit beta Chains: 0, 5
Molecule details ›
Chains: 0, 5
Length: 157 amino acids
Theoretical weight: 18.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13951 (Residues: 1-157; Coverage: 86%)
Gene name: CBFB
Sequence domains: Core binding factor beta subunit
Virion infectivity factor Chains: 1, 6
Molecule details ›
Chains: 1, 6
Length: 178 amino acids
Theoretical weight: 21.16 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P12504 (Residues: 1-176; Coverage: 92%)
Gene name: vif
Sequence domains: Retroviral Vif (Viral infectivity) protein
Elongin-B Chains: 3, 8
Molecule details ›
Chains: 3, 8
Length: 102 amino acids
Theoretical weight: 11.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15370 (Residues: 1-102; Coverage: 86%)
Gene names: ELOB, TCEB2
Sequence domains: Ubiquitin family
Elongin-C Chains: 4, 9
Molecule details ›
Chains: 4, 9
Length: 96 amino acids
Theoretical weight: 10.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15369 (Residues: 17-112; Coverage: 86%)
Gene names: ELOC, TCEB1
Sequence domains: Skp1 family, tetramerisation domain
Cullin-5 Chains: 2, 7
Molecule details ›
Chains: 2, 7
Length: 314 amino acids
Theoretical weight: 36.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q93034 (Residues: 12-320; Coverage: 40%)
Gene names: CUL5, VACM1
Sequence domains: Cullin family

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.54Å
Relevant EMDB volumes: EMD-29489
Expression system: Escherichia coli