Function and Biology

E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: negative regulation of intrinsic apoptotic signaling pathway
Cellular component: cytosol

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00452
Domain description: Apoptosis regulator proteins, Bcl-2 family
Occurring in:
  1. Bcl-2-like protein 1
The deposited structure of PDB entry 8fy0 contains 1 copy of Pfam domain PF00452 (Apoptosis regulator proteins, Bcl-2 family) in Bcl-2-like protein 1. Showing 1 copy in chain D.

PF02180
Domain description: Bcl-2 homology region 4
Occurring in:
  1. Bcl-2-like protein 1
The deposited structure of PDB entry 8fy0 contains 1 copy of Pfam domain PF02180 (Bcl-2 homology region 4) in Bcl-2-like protein 1. Showing 1 copy in chain D.

PF03931
Domain description: Skp1 family, tetramerisation domain
Occurring in:
  1. Elongin-C
The deposited structure of PDB entry 8fy0 contains 1 copy of Pfam domain PF03931 (Skp1 family, tetramerisation domain) in Elongin-C. Showing 1 copy in chain C.

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Elongin-B
The deposited structure of PDB entry 8fy0 contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Elongin-B. Showing 1 copy in chain B.

PF17211
Domain description: VHL box domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
The deposited structure of PDB entry 8fy0 contains 1 copy of Pfam domain PF17211 (VHL box domain) in von Hippel-Lindau disease tumor suppressor. Showing 1 copy in chain A.

PF01847
Domain description: VHL beta domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
The deposited structure of PDB entry 8fy0 contains 1 copy of Pfam domain PF01847 (VHL beta domain) in von Hippel-Lindau disease tumor suppressor. Showing 1 copy in chain A.