› 8fy5

Electron Microscopy
3.5Å resolution

Human TMEM175-LAMP1 full-length complex

Released:
DOI: 10.2210/pdb8fy5/pdb
PDB entry 8fy5 coloured by chain, front view.
PDB entry 8fy5 coloured by chain, side view.
PDB entry 8fy5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Zhang J, Zeng W, Han Y, Lee WR, Liou J, Jiang Y
Mol Cell (2023)
PMID: 37390818
Related structures: EMD-29553

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-219313 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Endosomal/lysosomal proton channel TMEM175 Chains: A, B
Molecule details ›
Chains: A, B
Length: 504 amino acids
Theoretical weight: 55.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BSA9 (Residues: 1-504; Coverage: 100%)
Gene name: TMEM175
Sequence domains: Endosomal/lysosomal potassium channel TMEM175
Lysosome-associated membrane glycoprotein 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 417 amino acids
Theoretical weight: 44.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P11279 (Residues: 1-417; Coverage: 100%)
Gene name: LAMP1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-29553
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Mitophagy for cardioprotection.
Titus et al. (2023)
1 more