Structure analysis

Crystal structure of human PARP1 ART domain bound to inhibitor UKTT5 (compound 10)

X-ray diffraction
2.8Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 11661.53 Å2
Buried surface area: 1188.5 Å2
Dissociation area: 129.14 Å2
Dissociation energy (ΔGdiss): -2.36 kcal/mol
Dissociation entropy (TΔSdiss): 0.13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140785

Macromolecules

Chain: A
Length: 271 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09874 (Residues: 788-1012; Coverage: 22%)
Gene names: ADPRT, PARP1, PPOL
Pfam: Poly(ADP-ribose) polymerase catalytic domain

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