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Neuraminidase of B/Massachusetts/02/2012 (Yamagata) in complex with 4 FNI17 Fab molecules

Electron Microscopy
2.3Å resolution
PDB entry 8g3z coloured by chain, front view.
PDB entry 8g3z coloured by chain, side view.
PDB entry 8g3z coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neuraminidase and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dodecamer
Accessible surface area: 79892.76 Å2
Buried surface area: 34059.51 Å2
Dissociation area: 4,374.06 Å2
Dissociation energy (ΔGdiss): -6.62 kcal/mol
Dissociation entropy (TΔSdiss): 55.66 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-234839

Macromolecules

FNI17 Fab heavy chain
Chains: E, G, H, J
Length: 231 amino acids
Theoretical weight: 24.58 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
FNI17 Fab heavy chain in PDB entry 8g3z, assembly 1, front view.
FNI17 Fab heavy chain in PDB entry 8g3z, assembly 1, side view.
FNI17 Fab heavy chain in PDB entry 8g3z, assembly 1, top view.
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FNI17 Fab light chain
Chains: F, I, K, L
Length: 215 amino acids
Theoretical weight: 23.48 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
FNI17 Fab light chain in PDB entry 8g3z, assembly 1, front view.
FNI17 Fab light chain in PDB entry 8g3z, assembly 1, side view.
FNI17 Fab light chain in PDB entry 8g3z, assembly 1, top view.
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Neuraminidase
Chains: A, B, C, D
Length: 496 amino acids
Theoretical weight: 55.15 KDa
Source organism: Influenza B virus
Expression system: Homo sapiens
UniProt:
  • Canonical: R4KV67 (Residues: 75-466; Coverage: 84%)
Gene name: NA
Pfam: Neuraminidase
Neuraminidase in PDB entry 8g3z, assembly 1, front view.
Neuraminidase in PDB entry 8g3z, assembly 1, side view.
Neuraminidase in PDB entry 8g3z, assembly 1, top view.
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