› 8g6m

Electron Microscopy
3.1Å resolution

HIV-1 CA lattice bound to IP6, pH 7.4

Released:
DOI: 10.2210/pdb8g6m/pdb
PDB entry 8g6m coloured by chain, front view.
PDB entry 8g6m coloured by chain, side view.
PDB entry 8g6m coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM.
Highland CM, Tan A, Ricaña CL, Briggs JAG, Dick RA
OpenAccess logo Proc Natl Acad Sci U S A 120 e2220545120 (2023)
PMID: 37094124
Related structures: EMD-29774

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 35-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146188 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 238 amino acids
Theoretical weight: 26.59 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P12493 (Residues: 132-363; Coverage: 46%)
Gene name: gag
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-29774
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Capsid-host interactions for HIV-1 ingress.
Jang et al. (2023)
3 other articles

1 mention without citation

Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM.
Highland et al. (2023)