Function and Biology

Porcine epidemic diarrhea virus core polymerase complex

Source organism: Porcine epidemic diarrhea virus
Biochemical function: transferase activity
Biological process: DNA-templated transcription
Cellular component: not assigned

EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

EC 2.1.1.57: Methyltransferase cap1

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase
Alternative Name(s):
  • Cap1-MTase
  • MTR1
  • Messenger RNA (nucleoside-2'-)-methyltransferase
  • Messenger ribonucleate nucleoside 2'-methyltransferase
  • S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
  • mRNA (nucleoside-2'-O)-methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF08716
Domain description: Coronavirus replicase NSP7
Occurring in:
  1. nsp7
The deposited structure of PDB entry 8g6r contains 1 copy of Pfam domain PF08716 (Coronavirus replicase NSP7) in nsp7. Showing 1 copy in chain C.

PF08717
Domain description: Coronavirus replicase NSP8
Occurring in:
  1. nsp8
The deposited structure of PDB entry 8g6r contains 1 copy of Pfam domain PF08717 (Coronavirus replicase NSP8) in nsp8. Showing 1 copy in chain B.

PF00680
Domain description: Viral RNA-dependent RNA polymerase
Occurring in:
  1. nsp12
The deposited structure of PDB entry 8g6r contains 1 copy of Pfam domain PF00680 (Viral RNA-dependent RNA polymerase) in nsp12. Showing 1 copy in chain A.

PF06478
Domain description: Coronavirus RNA-dependent RNA polymerase, N-terminal
Occurring in:
  1. nsp12
The deposited structure of PDB entry 8g6r contains 1 copy of Pfam domain PF06478 (Coronavirus RNA-dependent RNA polymerase, N-terminal) in nsp12. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR037204
Domain description: Non-structural protein NSP7 superfamily, coronavirus
Occurring in:
  1. nsp7
IPR014828
Domain description: Non-structural protein NSP7, coronavirus
Occurring in:
  1. nsp7
IPR037230
Domain description: Non-structural protein NSP8 superfamily, coronavirus
Occurring in:
  1. nsp8
IPR014829
Domain description: Non-structural protein NSP8, coronavirus
Occurring in:
  1. nsp8
IPR001205
Domain description: RNA-directed RNA polymerase, C-terminal domain
Occurring in:
  1. nsp12
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. nsp12
IPR046441
Domain description: RNA-dependent RNA polymerase, coronavirus
Occurring in:
  1. nsp12
IPR047570
Domain description: NSP12, interface domain, coronavirus
Occurring in:
  1. nsp12
IPR009469
Domain description: RNA-dependent RNA polymerase, N-terminal, coronavirus
Occurring in:
  1. nsp12
IPR044863
Domain description: Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domain
Occurring in:
  1. nsp12
IPR044356
Domain description: RNA-dependent RNA polymerase, alphacoronavirus
Occurring in:
  1. nsp12