› 8g7h

X-ray diffraction
1.81Å resolution

Crystal Structure of FosB from Bacillus cereus with Zinc and (1-hydroxypropan-2-yl)phosphonic acid

Released:
DOI: 10.2210/pdb8g7h/pdb
PDB entry 8g7h coloured by chain, front view.
PDB entry 8g7h coloured by chain, side view.
PDB entry 8g7h coloured by chain, top view.
Source organism: Bacillus cereus
Primary publication:
Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus.
Travis S, Green KD, Thamban Chandrika N, Pang AH, Frantom PA, Tsodikov OV, Garneau-Tsodikova S, Thompson MK
RSC Med Chem 14 947-956 (2023)
PMID: 37252104

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180944 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metallothiol transferase FosB Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 16.49 KDa
Source organism: Bacillus cereus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q739M9 (Residues: 1-138; Coverage: 100%)
Gene names: BCE_2111, fosB
Sequence domains: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

Ligands and Environments

5 bound ligands:
Ligand YRQ 2 x YRQ
Ligand FMT 7 x FMT
Ligand ZN 2 x ZN
Ligand MG 2 x MG
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 64.233Å b: 68.21Å c: 69.826Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.154 0.185
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Small molecule inhibitors of the fosfomycin resistance enzyme FosM from Mycobacterium abscessus.
Chiasson et al. (2023)