› 8g8a

X-ray diffraction
2.44Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-279507 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
DH1317.8 heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 225 amino acids
Theoretical weight: 24.01 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
DH1317.8 light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 216 amino acids
Theoretical weight: 23.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Transmembrane protein gp41 Chains: C, P
Molecule details ›
Chains: C, P
Length: 20 amino acids
Theoretical weight: 2.5 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 652-671; Coverage: 2%)
Gene name: env

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand NA 4 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 164.976Å b: 63.84Å c: 111.971Å
α: 90° β: 101.06° γ: 90°
R-values:
R R work R free
0.224 0.222 0.256
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

4 review citations

Beyond glycan barriers: non-cognate ligands and protein mimicry approaches to elicit broadly neutralizing antibodies for HIV-1.
Walimbwa et al. (2024)
3 more