› 8ga0

Electron Microscopy
3.5Å resolution

CLC-ec1 E202Y at pH 4.5 100mM Cl Turn

Released:
DOI: 10.2210/pdb8ga0/pdb
PDB entry 8ga0 coloured by chain, front view.
PDB entry 8ga0 coloured by chain, side view.
PDB entry 8ga0 coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Structural basis of pH-dependent activation in a CLC transporter.
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftici D, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A
Nat Struct Mol Biol (2024)
PMID: 38279055
Related structures: EMD-29883

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
H(+)/Cl(-) exchange transporter ClcA Chains: A, B
Molecule details ›
Chains: A, B
Length: 473 amino acids
Theoretical weight: 50.42 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P37019 (Residues: 1-473; Coverage: 100%)
Gene names: JW5012, b0155, clcA, eriC, yadQ
Sequence domains: Voltage gated chloride channel

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.5Å
Relevant EMDB volumes: EMD-29883
Expression system: Escherichia coli

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