› 8gbd

Solution NMR

Homo sapiens Zalpha mutant - P193A

Released:
DOI: 10.2210/pdb8gbd/pdb
PDB entry 8gbd coloured by chain, ensemble of 20 models, front view.
PDB entry 8gbd coloured by chain, ensemble of 20 models, side view.
PDB entry 8gbd coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Differential Structural Features of Two Mutant ADAR1p150 Zα Domains Cause Aicardi-Goutières Syndrome.
Langeberg CJ, Nichols PJ, Henen MA, Vicens Q, Vögeli B
J Mol Biol 168040 (2023)
PMID: 36889460

Function and Biology Details

Reaction catalysed: 
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Double-stranded RNA-specific adenosine deaminase Chain: A
Molecule details ›
Chain: A
Length: 84 amino acids
Theoretical weight: 9.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55265 (Residues: 140-202; Coverage: 5%)
Gene names: ADAR, ADAR1, DSRAD, G1P1, IFI4
Sequence domains: Adenosine deaminase z-alpha domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 64%
Refinement method: na
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing.
Guo et al. (2023)
1 more

1 mention without citation

Differential Structural Features of Two Mutant ADAR1p150 Zα Domains Associated with Aicardi-Goutières Syndrome.
Langeberg et al. (2023)