8gcr

Electron Microscopy
3.38Å resolution

HPV16 E6-E6AP-p53 complex

Released:

Function and Biology Details

Reaction catalysed:
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-272185 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Maltose/maltodextrin-binding periplasmic protein; Protein E6 Chain: A
Molecule details ›
Chain: A
Length: 541 amino acids
Theoretical weight: 61.19 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 27-396; Coverage: 100%)
  • Canonical: P03126 (Residues: 1-158; Coverage: 100%)
Gene names: E6, JW3994, b4034, malE
Sequence domains:
Cellular tumor antigen p53 Chain: B
Molecule details ›
Chain: B
Length: 220 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 94-312; Coverage: 56%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain
Ubiquitin-protein ligase E3A Chain: R

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.38Å
Relevant EMDB volumes: EMD-29941
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda