› 8ge0

X-ray diffraction
2.4Å resolution

Crystal structure of JADE1 PZP domain in complex with Histone H3

Released:
DOI: 10.2210/pdb8ge0/pdb
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PDB entry 8ge0 coloured by chain, front view.
PDB entry 8ge0 coloured by chain, side view.
PDB entry 8ge0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Guiding the HBO1 complex function through the JADE subunit.
Gaurav N, Kanai A, Lachance C, Cox KL, Liu J, Grzybowski AT, Saksouk N, Klein BJ, Komata Y, Asada S, Ruthenburg AJ, Poirier MG, Côté J, Yokoyama A, Kutateladze TG
Nat Struct Mol Biol (2024)
PMID: 38448574

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274140 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone H3.1; Protein Jade-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 190 amino acids
Theoretical weight: 20.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68431 (Residues: 2-14; Coverage: 10%)
  • Canonical: Q6IE81 (Residues: 201-373; Coverage: 21%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, JADE1, KIAA1807, PHF17
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 15 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P41212
Unit cell:
a: 78.16Å b: 78.16Å c: 222.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.241
Expression system: Escherichia coli

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