› 8gfa

Electron Microscopy
2.29Å resolution

Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791

Released:
DOI: 10.2210/pdb8gfa/pdb
PDB entry 8gfa coloured by chain, front view.
PDB entry 8gfa coloured by chain, side view.
PDB entry 8gfa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human TRPV1 structure and inhibition by the analgesic SB-366791.
Neuberger A, Oda M, Nikolaev YA, Nadezhdin KD, Gracheva EO, Bagriantsev SN, Sobolevsky AI
OpenAccess logo Nat Commun 14 2451 (2023)
PMID: 37117175
Related structures: EMD-29983

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1102 amino acids
Theoretical weight: 124.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NER1 (Residues: 2-839; Coverage: 100%)
Gene names: TRPV1, VR1
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand POV 36 x POV
Ligand ZEI 4 x ZEI
Ligand DU0 4 x DU0
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.29Å
Relevant EMDB volumes: EMD-29983
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases.
Wang et al. (2023)
1 more

1 mention without citation

Phenolic Compounds and Capsaicinoids in Three Capsicum annuum Varieties: From Analytical Characterization to In Silico Hypotheses on Biological Activity.
Giordano et al. (2023)