PDB 8gft structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reactions catalysed:

ATP + a protein = ADP + a phosphoprotein

[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

Biochemical function:

ATP binding

Biological process:

protein stabilization

Cellular component:

protein folding chaperone complex

Structure analysis Details

Assembly composition:

hetero pentamer (preferred)

PDBe Complex ID:

PDB-CPX-215134 (preferred)

Entry contents:

4 distinct polypeptide molecules

Macromolecules (4 distinct):

Heat shock protein HSP 90-beta Chains: A, B

Molecule details ›

Chains: A, B
Length: 727 amino acids
Theoretical weight: 83.6 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:

Canonical: P08238 (Residues: 1-724; Coverage: 100%)

Gene names: HSP90AB1, HSP90B, HSPC2, HSPC3, HSPCB
Sequence domains:

Hsp90 co-chaperone Cdc37 Chain: C

Molecule details ›

Chain: C
Length: 384 amino acids
Theoretical weight: 45.35 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:

Canonical: Q16543 (Residues: 1-378; Coverage: 100%)

Gene names: CDC37, CDC37A
Sequence domains:

RAF proto-oncogene serine/threonine-protein kinase Chain: D

Molecule details ›

Chain: D
Length: 304 amino acids
Theoretical weight: 34.93 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:

Canonical: P04049 (Residues: 336-618; Coverage: 44%)

Gene names: RAF, RAF1
Sequence domains: Protein kinase domain

Serine/threonine-protein phosphatase 5 Chain: E

Molecule details ›

Chain: E
Length: 503 amino acids
Theoretical weight: 57.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt: