› 8gh0

Electron Microscopy
4Å resolution

Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #19 of 20)

Released:
DOI: 10.2210/pdb8gh0/pdb
PDB entry 8gh0 coloured by chain, front view.
PDB entry 8gh0 coloured by chain, side view.
PDB entry 8gh0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Time-resolved cryo-EM of G-protein activation by a GPCR.
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024)
PMID: 38480881
Related structures: EMD-40027

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139613 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2 adrenergic receptor Chain: R
Molecule details ›
Chain: R
Length: 460 amino acids
Theoretical weight: 51.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07550 (Residues: 1-24, 25-365, 366-413; Coverage: 100%)
Gene names: ADRB2, ADRB2R, B2AR
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

1 bound ligand:
Ligand G1I 1 x G1I
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-40027
Expression system: Spodoptera frugiperda

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