EC 1.13.11.33: Arachidonate 15-lipoxygenase
Reaction catalysed:
Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
Systematic name:
Arachidonate:oxygen 15-oxidoreductase
Alternative Name(s):
- 15-lipoxygenase
- Arachidonate omega(6) lipoxygenase
- Linoleic acid omega(6)-lipoxygenase
- Omega(6) lipoxygenase
EC 1.13.11.31: Arachidonate 12-lipoxygenase
Reaction catalysed:
Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
Systematic name:
Arachidonate:oxygen 12-oxidoreductase
Alternative Name(s):
- 12-Delta-lipoxygenase
- 12-lipoxygenase
- 12S-lipoxygenase
- C-12 lipoxygenase
- Delta(12)-lipoxygenase
- LTA(4) synthase
- Leukotriene A(4) synthase
GO terms
Biochemical function:
- dioxygenase activity
- arachidonate 15-lipoxygenase activity
- hepoxilin-epoxide hydrolase activity
- metal ion binding
- hydrolase activity
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- linoleate 13S-lipoxygenase activity
- protein binding
- iron ion binding
- arachidonate 12(S)-lipoxygenase activity
Biological process:
- lipoxin B4 biosynthetic process
- lipoxin A4 biosynthetic process
- leukotriene A4 metabolic process
- negative regulation of platelet aggregation
- establishment of skin barrier
- hepoxilin biosynthetic process
- linoleic acid metabolic process
- superoxide anion generation
- lipid oxidation
- unsaturated fatty acid metabolic process
- fatty acid oxidation
- lipoxygenase pathway
- arachidonic acid metabolic process
- negative regulation of muscle cell apoptotic process
- icosanoid metabolic process
- fatty acid metabolic process
- lipid metabolic process
- long-chain fatty acid metabolic process
Protein families (Pfam)
