› 8ghk

Electron Microscopy
3.47Å resolution

CryoEM structure of Influenza A virus A/Melbourner/1/1946 (H1N1) hemagglutinin bound to GS10-X6-BE4 Fab

Released:
DOI: 10.2210/pdb8ghk/pdb
PDB entry 8ghk coloured by chain, front view.
PDB entry 8ghk coloured by chain, side view.
PDB entry 8ghk coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6.
Nagashima KA, Dzimianski JV, Yang M, Abendroth J, Sautto GA, Ross TM, DuBois RM, Edwards TE, Mousa JJ
Structure (2024)
PMID: 38810648
Related structures: EMD-40046

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-246409 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin HA1 chain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 480 amino acids
Theoretical weight: 53.99 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A0A6G5T7C5 (Residues: 18-506; Coverage: 85%)
Gene name: HA
Sequence domains: Haemagglutinin
GS10-X6-BE4 Fab Heavy chain Chains: H, M
Molecule details ›
Chains: H, M
Length: 142 amino acids
Theoretical weight: 16.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
GS10-X6-BE4 Fab light chain Chains: L, N
Molecule details ›
Chains: L, N
Length: 126 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.47Å
Relevant EMDB volumes: EMD-40046
Expression systems:
  • Spodoptera frugiperda
  • Homo sapiens

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