› 8ghz

Electron Microscopy
2.78Å resolution

Cryo-EM structure of fish immunogloblin M-Fc

Released:
DOI: 10.2210/pdb8ghz/pdb
PDB entry 8ghz coloured by chain, front view.
PDB entry 8ghz coloured by chain, side view.
PDB entry 8ghz coloured by chain, top view.
Source organism: Oncorhynchus mykiss
Primary publication:
The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function.
Lyu M, Malyutin AG, Stadtmueller BM
OpenAccess logo Nat Commun 14 7583 (2023)
PMID: 37989996
Related structures: EMD-40054

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240687 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Ig-like domain-containing protein Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 237 amino acids
Theoretical weight: 27 KDa
Source organism: Oncorhynchus mykiss
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A8C7NK04 (Residues: 337-434, 435-566; Coverage: 41%)
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.78Å
Relevant EMDB volumes: EMD-40054
Expression system: Homo sapiens

Quick links