› 8gie

X-ray diffraction
1.85Å resolution

Crystal structure of a designed single-component Plasmodium falciparum AMA1-RON2L insertion fusion immunogen 2

Released:
DOI: 10.2210/pdb8gie/pdb
Model geometry
Fit model/data
PDB entry 8gie coloured by chain, front view.
PDB entry 8gie coloured by chain, side view.
PDB entry 8gie coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.
Patel PN, Dickey TH, Diouf A, Salinas ND, McAleese H, Ouahes T, Long CA, Miura K, Lambert LE, Tolia NH
OpenAccess logo Nat Commun 14 5345 (2023)
PMID: 37660103

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274988 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apical membrane antigen 1; Rhoptry neck protein 2 Chain: A
Molecule details ›
Chain: A
Length: 349 amino acids
Theoretical weight: 38.59 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7KQK5 (Residues: 104-259, 273-438; Coverage: 48%)
  • Canonical: Q8IKV6 (Residues: 2021-2059; Coverage: 2%)
Gene names: PF3D7_1133400, PF3D7_1452000
Sequence domains: Apical membrane antigen 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 40.63Å b: 62.83Å c: 60.47Å
α: 90° β: 96.47° γ: 90°
R-values:
R R work R free
0.192 0.191 0.212
Expression system: Homo sapiens

Quick links

Citations

3 review citations

The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for <i>Plasmodium falciparum</i>.
Takashima et al. (2024)
2 more

1 mention without citation

Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.
Patel et al. (2023)