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E. coli clamp loader with closed clamp

Source organism: Escherichia coli K-12
Biochemical function: DNA-directed DNA polymerase activity
Biological process: DNA replication
Cellular component: DNA polymerase III complex

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EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF13177
Domain description: DNA polymerase III, delta subunit
Occurring in:
  1. DNA polymerase III subunit tau
  2. DNA polymerase III subunit delta'
The deposited structure of PDB entry 8giy contains 3 copies of Pfam domain PF13177 (DNA polymerase III, delta subunit) in DNA polymerase III subunit tau. Showing 1 copy in chain C.
The deposited structure of PDB entry 8giy contains 1 copy of Pfam domain PF13177 (DNA polymerase III, delta subunit) in DNA polymerase III subunit delta'. Showing 1 copy in chain E.

PF12169
Domain description: DNA polymerase III subunits gamma and tau domain III
Occurring in:
  1. DNA polymerase III subunit tau
The deposited structure of PDB entry 8giy contains 3 copies of Pfam domain PF12169 (DNA polymerase III subunits gamma and tau domain III) in DNA polymerase III subunit tau. Showing 1 copy in chain C.

PF22608
Domain description: DNA polymerase III clamp loader subunit, ATPase lid domain
Occurring in:
  1. DNA polymerase III subunit tau

PF02768
Domain description: DNA polymerase III beta subunit, C-terminal domain
Occurring in:
  1. Beta sliding clamp
The deposited structure of PDB entry 8giy contains 2 copies of Pfam domain PF02768 (DNA polymerase III beta subunit, C-terminal domain) in Beta sliding clamp. Showing 1 copy in chain G [auth H].

PF02767
Domain description: DNA polymerase III beta subunit, central domain
Occurring in:
  1. Beta sliding clamp
The deposited structure of PDB entry 8giy contains 2 copies of Pfam domain PF02767 (DNA polymerase III beta subunit, central domain) in Beta sliding clamp. Showing 1 copy in chain G [auth H].

PF00712
Domain description: DNA polymerase III beta subunit, N-terminal domain
Occurring in:
  1. Beta sliding clamp
The deposited structure of PDB entry 8giy contains 2 copies of Pfam domain PF00712 (DNA polymerase III beta subunit, N-terminal domain) in Beta sliding clamp. Showing 1 copy in chain G [auth H].

PF03603
Domain description: DNA polymerase III psi subunit
Occurring in:
  1. DNA polymerase III subunit psi
The deposited structure of PDB entry 8giy contains 1 copy of Pfam domain PF03603 (DNA polymerase III psi subunit) in DNA polymerase III subunit psi. Showing 1 copy in chain F.

PF09115
Domain description: DNA polymerase III, delta subunit, C terminal
Occurring in:
  1. DNA polymerase III subunit delta'
The deposited structure of PDB entry 8giy contains 1 copy of Pfam domain PF09115 (DNA polymerase III, delta subunit, C terminal) in DNA polymerase III subunit delta'. Showing 1 copy in chain E.

PF21500
Domain description: DNA polymerase III subunit delta', AAA+ ATPase lid domain
Occurring in:
  1. DNA polymerase III subunit delta'
The deposited structure of PDB entry 8giy contains 1 copy of Pfam domain PF21500 (DNA polymerase III subunit delta', AAA+ ATPase lid domain) in DNA polymerase III subunit delta'. Showing 1 copy in chain E.

PF14840
Domain description: Processivity clamp loader gamma complex DNA pol III C-term
Occurring in:
  1. DNA polymerase III subunit delta
The deposited structure of PDB entry 8giy contains 1 copy of Pfam domain PF14840 (Processivity clamp loader gamma complex DNA pol III C-term) in DNA polymerase III subunit delta. Showing 1 copy in chain A.

PF06144
Domain description: DNA polymerase III, delta subunit
Occurring in:
  1. DNA polymerase III subunit delta
The deposited structure of PDB entry 8giy contains 1 copy of Pfam domain PF06144 (DNA polymerase III, delta subunit) in DNA polymerase III subunit delta. Showing 1 copy in chain A.

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