› 8gjc

X-ray diffraction
1.43Å resolution

X-ray crystallographic structure of a beta-hairpin peptide derived from Abeta 17-35. (ORN)LVFFAED(ORN)GAI(N-Me-Ile)GLM

Released:
DOI: 10.2210/pdb8gjc/pdb
PDB entry 8gjc coloured by chain, front view.
PDB entry 8gjc coloured by chain, side view.
PDB entry 8gjc coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
β-Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides.
Ruttenberg SM, Kreutzer AG, Truex NL, Nowick JS
OpenAccess logo Biochemistry (2024)
PMID: 38163326

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-238955 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
beta-hairpin peptide derived from Abeta 17-35 Chains: A, B
Molecule details ›
Chains: A, B
Length: 15 amino acids
Theoretical weight: 1.61 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand MET 2 x MET
Ligand TFA 3 x TFA
Ligand PEG 1 x PEG
2 modified residues:
Ligand ORN 4 x ORN
Ligand IML 2 x IML

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P3221
Unit cell:
a: 38.164Å b: 38.164Å c: 32.054Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.16 0.155 0.181
Expression system: Not provided

Quick links

Citations

1 mention without citation

β-Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides.
Ruttenberg et al. (2024)