› 8gjl

Electron Microscopy
3.44Å resolution

multi-drug efflux pump RE-CmeB bound with Ciprofloxacin

Released:
DOI: 10.2210/pdb8gjl/pdb
PDB entry 8gjl coloured by chain, front view.
PDB entry 8gjl coloured by chain, side view.
PDB entry 8gjl coloured by chain, top view.
Source organism: Campylobacter jejuni
Primary publication:
Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Zhang Z, Lizer N, Wu Z, Morgan CE, Yan Y, Zhang Q, Yu EW
OpenAccess logo Microbiol Spectr 11 e0119723 (2023)
PMID: 37289051
Related structures: EMD-40093

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-216471 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SSD domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1039 amino acids
Theoretical weight: 114.12 KDa
Source organism: Campylobacter jejuni
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A1C9A1J1 (Residues: 1-1039; Coverage: 100%)
Gene name: cmeB
Sequence domains: AcrB/AcrD/AcrF family

Ligands and Environments

1 bound ligand:
Ligand CPF 1 x CPF
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.44Å
Relevant EMDB volumes: EMD-40093
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Exploring the World of Membrane Proteins: Techniques and Methods for Understanding Structure, Function, and Dynamics.
Boulos et al. (2023)

1 mention without citation

Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Zhang et al. (2023)