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Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dG

X-ray diffraction
2.567Å resolution
PDB entry 8gml coloured by chain, front view.
PDB entry 8gml coloured by chain, side view.
PDB entry 8gml coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA polymerase eta and DNA
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Multimeric state: hetero trimer
Accessible surface area: 21759.69 Å2
Buried surface area: 3929.27 Å2
Dissociation area: 1,280.42 Å2
Dissociation energy (ΔGdiss): 29.63 kcal/mol
Dissociation entropy (TΔSdiss): 10 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-270477

Macromolecules

DNA polymerase eta
Chain: A
Length: 432 amino acids
Theoretical weight: 48.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y253 (Residues: 1-432; Coverage: 61%)
Gene names: POLH, RAD30, RAD30A, XPV
Pfam:
DNA polymerase eta in PDB entry 8gml, assembly 1, front view.
DNA polymerase eta in PDB entry 8gml, assembly 1, side view.
DNA polymerase eta in PDB entry 8gml, assembly 1, top view.
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DNA chain T
Name: DNA (5'-D(P*TP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3')
Representative chains: T
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.58 KDa
DNA (5'-D(P*TP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3') in PDB entry 8gml, assembly 1, front view.
DNA (5'-D(P*TP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3') in PDB entry 8gml, assembly 1, side view.
DNA (5'-D(P*TP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3') in PDB entry 8gml, assembly 1, top view.
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DNA chain P
Name: DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3')
Representative chains: P
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 8 nucleotides
Theoretical weight: 2.51 KDa
DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3') in PDB entry 8gml, assembly 1, front view.
DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3') in PDB entry 8gml, assembly 1, side view.
DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3') in PDB entry 8gml, assembly 1, top view.
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