› 8go9

Electron Microscopy
3.35Å resolution

Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Atypical chemokine receptor 2, ACKR2 (D6R)

Released:
DOI: 10.2210/pdb8go9/pdb
PDB entry 8go9 coloured by chain, front view.
PDB entry 8go9 coloured by chain, side view.
PDB entry 8go9 coloured by chain, top view.
Source organisms:
Primary publication:
Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors.
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science 383 101-108 (2024)
PMID: 38175886
Related structures: EMD-34174

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-237553 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Beta-arrestin-2 Chains: A, F
Molecule details ›
Chains: A, F
Length: 420 amino acids
Theoretical weight: 47.22 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P32120 (Residues: 1-420; Coverage: 100%)
Gene name: ARRB2
Sequence domains:
Fab30 Heavy Chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 237 amino acids
Theoretical weight: 25.51 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Fab30 Light Chain Chains: C, E
Molecule details ›
Chains: C, E
Length: 215 amino acids
Theoretical weight: 23.44 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Atypical chemokine receptor 2 Chains: G, H
Molecule details ›
Chains: G, H
Length: 18 amino acids
Theoretical weight: 2.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O00590 (Residues: 338-355; Coverage: 5%)
Gene names: ACKR2, CCBP2, CCR10, CMKBR9, D6

Ligands and Environments

No bound ligands
2 modified residues:
Ligand TPO 4 x TPO
Ligand SEP 12 x SEP

Experiments and Validation Details

Entry percentile scores
Resolution: 3.35Å
Relevant EMDB volumes: EMD-34174
Expression systems:
  • Escherichia coli
  • Not provided

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