Structure analysis

Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab

Electron Microscopy
3.7Å resolution
Assembly composition:
hetero heptamer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero heptamer
Accessible surface area: 159640.72 Å2
Buried surface area: 34246.52 Å2
Dissociation area: 1,414.73 Å2
Dissociation energy (ΔGdiss): -22.82 kcal/mol
Dissociation entropy (TΔSdiss): 38.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-276131

Macromolecules

Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.59 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Pfam:

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Chains: H, I
Length: 120 amino acids
Theoretical weight: 13.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

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Chains: J, K
Length: 109 amino acids
Theoretical weight: 11.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

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