› 8gtt

Electron Microscopy
3.2Å resolution

Cryo-EM structure of human Pannexin1 resembling Pannexin2 pore with W74R/R75Dmutations

Released:
DOI: 10.2210/pdb8gtt/pdb
PDB entry 8gtt coloured by chain, front view.
PDB entry 8gtt coloured by chain, side view.
PDB entry 8gtt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms.
Hussain N, Apotikar A, Pidathala S, Mukherjee S, Burada AP, Sikdar SK, Vinothkumar KR, Penmatsa A
OpenAccess logo Nat Commun 15 2942 (2024)
PMID: 38580658
Related structures: EMD-34267

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188716 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pannexin-1 Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 434 amino acids
Theoretical weight: 49.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96RD7 (Residues: 1-426; Coverage: 100%)
Gene names: MRS1, PANX1, UNQ2529/PRO6028
Sequence domains: Innexin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-34267
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Mefloquine-induced conformational shift in Cx36 N-terminal helix leading to channel closure mediated by lipid bilayer.
Cho et al. (2024)