› 8gvh

Electron Microscopy
3.32Å resolution

Human AE2 in acidic KNO3

Released:
DOI: 10.2210/pdb8gvh/pdb
PDB entry 8gvh coloured by chain, front view.
PDB entry 8gvh coloured by chain, side view.
PDB entry 8gvh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis of the pH-homeostasis mediated by the Cl-/HCO3- exchanger, AE2.
Zhang Q, Jian L, Yao D, Rao B, Xia Y, Hu K, Li S, Shen Y, Cao M, Qin A, Zhao J, Cao Y
OpenAccess logo Nat Commun 14 1812 (2023)
PMID: 37002221
Related structures: EMD-34293

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-199839 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anion exchange protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1241 amino acids
Theoretical weight: 137.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04920 (Residues: 1-1241; Coverage: 100%)
Gene names: AE2, EPB3L1, HKB3, MPB3L, SLC4A2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand Y01 2 x Y01
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.32Å
Relevant EMDB volumes: EMD-34293
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP2.
Lu et al. (2023)
1 more

1 mention without citation

Structural and functional insights into the lipid regulation of human anion exchanger 2.
Zhang et al. (2024)