› 8gww

X-ray diffraction
3Å resolution

Small-molecule Allosteric Regulation Mechanism of SHP2

Released:
DOI: 10.2210/pdb8gww/pdb
PDB entry 8gww coloured by chain, front view.
PDB entry 8gww coloured by chain, side view.
PDB entry 8gww coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Luo Y, Zhu J, Yu K, Liu B

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 525 amino acids
Theoretical weight: 60.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 1-525; Coverage: 89%)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand KID 2 x KID
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 56.499Å b: 91.17Å c: 213.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.24 0.288
Expression system: Escherichia coli

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