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Cryo-EM structure of human CEPT1

Source organism: Homo sapiens
Biochemical function: 1-alkenyl-2-acylglycerol choline phosphotransferase activity
Biological process: phospholipid biosynthetic process
Cellular component: nuclear membrane

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EC 2.7.8.22: 1-alkenyl-2-acylglycerol choline phosphotransferase

Reaction catalysed:
CDP-choline + 1-alkenyl-2-acylglycerol = CMP + plasmenylcholine
Systematic name:
CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase
Alternative Name(s):
  • CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase

EC 2.7.8.2: Diacylglycerol cholinephosphotransferase

Reaction catalysed:
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine
Systematic name:
CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase
Alternative Name(s):
  • 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase
  • 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase
  • 1-alkyl-2-acetylglycerol cholinephosphotransferase
  • Alkylacylglycerol choline phosphotransferase
  • Alkylacylglycerol cholinephosphotransferase
  • CDP choline:1,2-diacylglycerol cholinephosphotransferase
  • CDP-choline diglyceride phosphotransferase
  • CDP-choline:1,2-diacylglycerol cholinephosphotransferase
  • CPT
  • Cholinephosphotransferase
  • Cytidine diphosphocholine glyceride transferase
  • Cytidine diphosphorylcholine diglyceride transferase
  • Diacylglycerol choline phosphotransferase
  • Phosphocholine diacylglyceroltransferase
  • Phosphorylcholine--glyceride transferase
  • sn-1,2-diacylglycerol cholinephosphotransferase

EC 2.7.8.1: Ethanolaminephosphotransferase

Reaction catalysed:
CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine
Systematic name:
CDP-ethanolamine:1,2-diacyl-sn-glycerol ethanolaminephosphotransferase
Alternative Name(s):
  • CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
  • CDPethanolamine diglyceride phosphotransferase
  • Diacylglycerol ethanolaminephosphotransferase
  • EPT
  • Phosphorylethanolamine-glyceride transferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01066
Domain description: CDP-alcohol phosphatidyltransferase
Occurring in:
  1. Choline/ethanolaminephosphotransferase 1
The deposited structure of PDB entry 8gyx contains 2 copies of Pfam domain PF01066 (CDP-alcohol phosphatidyltransferase) in Choline/ethanolaminephosphotransferase 1. Showing 1 copy in chain B [auth A].

InterPro InterPro annotations
IPR000462
Domain description: CDP-alcohol phosphatidyltransferase
Occurring in:
  1. Choline/ethanolaminephosphotransferase 1
IPR014472
Domain description: Choline/ethanolamine phosphotransferase
Occurring in:
  1. Choline/ethanolaminephosphotransferase 1
IPR043130
Domain description: CDP-alcohol phosphatidyltransferase, transmembrane domain
Occurring in:
  1. Choline/ethanolaminephosphotransferase 1

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