8gz1

Electron Microscopy
3.4Å resolution

Cryo-EM structure of human NaV1.6/beta1/beta2,apo state

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-130221 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Sodium channel subunit beta-1 Chain: D
Molecule details ›
Chain: D
Length: 218 amino acids
Theoretical weight: 24.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07699 (Residues: 1-218; Coverage: 100%)
Gene name: SCN1B
Sequence domains: Immunoglobulin V-set domain
Sodium channel protein type 8 subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 1980 amino acids
Theoretical weight: 225.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UQD0 (Residues: 1-1980; Coverage: 100%)
Gene names: MED, SCN8A
Sequence domains:
Sodium channel subunit beta-2 Chain: C
Molecule details ›
Chain: C
Length: 215 amino acids
Theoretical weight: 24.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60939 (Residues: 1-215; Coverage: 100%)
Gene names: SCN2B, UNQ326/PRO386
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-34387
Expression system: Homo sapiens