Function and Biology Details
Reactions catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tridecamer (preferred)
PDBe Complex ID:
PDB-CPX-231826 (preferred)
Entry contents:
12 distinct polypeptide molecules
Macromolecules (12 distinct):
COP9 signalosome complex subunit 1
Chain: A
Molecule details ›
Chain: A
Length: 527 amino acids
Theoretical weight: 59.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt: Gene names: COPS1, CSN1, GPS1
Sequence domains:
Length: 527 amino acids
Theoretical weight: 59.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt: Gene names: COPS1, CSN1, GPS1
Sequence domains:
COP9 signalosome complex subunit 2
Chain: B
Molecule details ›
Chain: B
Length: 443 amino acids
Theoretical weight: 51.66 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: PCI domain
Length: 443 amino acids
Theoretical weight: 51.66 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P61201 (Residues: 1-443; Coverage: 100%)
Sequence domains: PCI domain
COP9 signalosome complex subunit 3
Chain: C
Molecule details ›
Chain: C
Length: 423 amino acids
Theoretical weight: 47.92 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 423 amino acids
Theoretical weight: 47.92 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9UNS2 (Residues: 1-423; Coverage: 100%)
Sequence domains:
COP9 signalosome complex subunit 4
Chain: D
Molecule details ›
Chain: D
Length: 406 amino acids
Theoretical weight: 46.32 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 406 amino acids
Theoretical weight: 46.32 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9BT78 (Residues: 1-406; Coverage: 100%)
Sequence domains:
COP9 signalosome complex subunit 5
Chain: E
Molecule details ›
Chain: E
Length: 334 amino acids
Theoretical weight: 37.55 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 334 amino acids
Theoretical weight: 37.55 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q92905 (Residues: 1-334; Coverage: 100%)
Sequence domains:
COP9 signalosome complex subunit 6
Chain: F
Molecule details ›
Chain: F
Length: 327 amino acids
Theoretical weight: 36.2 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 327 amino acids
Theoretical weight: 36.2 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q7L5N1 (Residues: 1-327; Coverage: 100%)
Sequence domains:
COP9 signalosome complex subunit 7b
Chain: G
Molecule details ›
Chain: G
Length: 264 amino acids
Theoretical weight: 29.66 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 264 amino acids
Theoretical weight: 29.66 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9H9Q2 (Residues: 1-264; Coverage: 100%)
Sequence domains:
COP9 signalosome complex subunit 8
Chain: H
Molecule details ›
Chain: H
Length: 209 amino acids
Theoretical weight: 23.25 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: CSN8/PSMD8/EIF3K family
Length: 209 amino acids
Theoretical weight: 23.25 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q99627 (Residues: 1-209; Coverage: 100%)
Sequence domains: CSN8/PSMD8/EIF3K family
Kelch repeat and BTB domain-containing protein 2
Chains: I, M
Molecule details ›
Cullin-3
Chain: L
Molecule details ›
Chain: L
Length: 768 amino acids
Theoretical weight: 89.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 768 amino acids
Theoretical weight: 89.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q13618 (Residues: 1-768; Coverage: 100%)
Sequence domains:
E3 ubiquitin-protein ligase RBX1
Chain: R
Molecule details ›
Chain: R
Length: 108 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: RING-H2 zinc finger domain
Length: 108 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P62877 (Residues: 1-108; Coverage: 100%)
Sequence domains: RING-H2 zinc finger domain
NEDD8
Chain: N
Molecule details ›
Chain: N
Length: 76 amino acids
Theoretical weight: 8.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 76 amino acids
Theoretical weight: 8.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q15843 (Residues: 1-76; Coverage: 94%)
Sequence domains: Ubiquitin family