› 8h94

Electron Microscopy
2.9Å resolution

Structure of mouse SCMC bound with KH domain of FILIA

Released:
DOI: 10.2210/pdb8h94/pdb
PDB entry 8h94 coloured by chain, front view.
PDB entry 8h94 coloured by chain, side view.
PDB entry 8h94 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of the subcortical maternal complex and its implications in reproductive disorders.
Chi P, Ou G, Qin D, Han Z, Li J, Xiao Q, Gao Z, Xu C, Qi Q, Liu Q, Liu S, Li J, Guo L, Lu Y, Chen J, Wang X, Shi H, Li L, Deng D
Nat Struct Mol Biol (2024)
PMID: 38177687
Related structures: EMD-34554

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-238795 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
NACHT, LRR and PYD domains-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 1059 amino acids
Theoretical weight: 119.82 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9R1M5 (Residues: 105-1163; Coverage: 91%)
Gene names: Mater, Nalp5, Nlrp5
Sequence domains:
Transducin-like enhancer protein 6 Chain: B
Molecule details ›
Chain: B
Length: 581 amino acids
Theoretical weight: 65.19 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9WVB3 (Residues: 1-581; Coverage: 100%)
Gene names: Grg6, Tle6
Oocyte-expressed protein homolog Chain: C
Molecule details ›
Chain: C
Length: 164 amino acids
Theoretical weight: 18.48 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9CWE6 (Residues: 1-164; Coverage: 100%)
Gene names: Oep19, Ooep, Sddr
Sequence domains: KH-like RNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-34554
Expression system: Spodoptera frugiperda

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