8h9s

Electron Microscopy
2.53Å resolution

Human ATP synthase state 1 (combined)

Released:
Source organism: Homo sapiens
Related structures: EMD-34580

Function and Biology Details

Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
PDBe Complex ID:
PDB-CPX-271868 (preferred)
Entry contents:
17 distinct polypeptide molecules
Macromolecules (17 distinct):
ATP synthase F(0) complex subunit B1, mitochondrial Chain: K
Molecule details ›
Chain: K
Length: 214 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P24539 (Residues: 43-256; Coverage: 84%)
Gene names: ATP5F1, ATP5PB
Sequence domains: Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
ATP synthase-coupling factor 6, mitochondrial Chain: L
Molecule details ›
Chain: L
Length: 108 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18859 (Residues: 1-108; Coverage: 100%)
Gene names: ATP5A, ATP5J, ATP5PF, ATPM
Sequence domains: Mitochondrial ATP synthase coupling factor 6
ATP synthase subunit d, mitochondrial Chain: M
ATP synthase subunit alpha, mitochondrial Chains: A, B, C
ATP synthase subunit beta, mitochondrial Chains: D, E, F
ATP synthase subunit gamma, mitochondrial Chain: G
ATPase inhibitor, mitochondrial Chain: J
ATP synthase subunit O, mitochondrial Chain: O
ATP synthase F(0) complex subunit C1, mitochondrial Chains: 1, 2, 3, 4, 5, 6, 7, 8
ATP synthase subunit delta, mitochondrial Chain: H
ATP synthase subunit epsilon, mitochondrial Chain: I
ATP synthase subunit a Chain: N
ATP synthase subunit ATP5MJ, mitochondrial Chain: P
ATP synthase protein 8 Chain: Q
ATP synthase subunit f, mitochondrial Chain: R
ATP synthase subunit g, mitochondrial Chain: S
ATP synthase subunit e, mitochondrial Chain: T

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.53Å
Relevant EMDB volumes: EMD-34580