› 8hao

Electron Microscopy
3.76Å resolution

Human parathyroid hormone receptor-1 dimer

Released:
DOI: 10.2210/pdb8hao/pdb
PDB entry 8hao coloured by chain, front view.
PDB entry 8hao coloured by chain, side view.
PDB entry 8hao coloured by chain, top view.
Source organisms:
Primary publication:
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1.
Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE
Acta Pharmacol Sin (2022)
PMID: 36482086
Related structures: EMD-34598

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-275990 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Guanine nucleotide-binding protein G(s) subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 361 amino acids
Theoretical weight: 41.88 KDa
Source organism: Bos taurus
Expression system: Trichoplusia ni
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 400 amino acids
Theoretical weight: 43.71 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P54311 (Residues: 1-340; Coverage: 100%)
Gene name: Gnb1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chains: E, G
Molecule details ›
Chains: E, G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Bos taurus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63212 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain
Nanobody 35 Chains: F, N
Molecule details ›
Chains: F, N
Length: 140 amino acids
Theoretical weight: 15.34 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Parathyroid hormone Chains: H, P
Molecule details ›
Chains: H, P
Length: 35 amino acids
Theoretical weight: 4.12 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01270 (Residues: 32-65; Coverage: 38%)
Gene name: PTH
Sequence domains: Parathyroid hormone family
Parathyroid hormone/parathyroid hormone-related peptide receptor Chains: I, R
Molecule details ›
Chains: I, R
Length: 476 amino acids
Theoretical weight: 54.51 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q03431 (Residues: 27-502; Coverage: 84%)
Gene names: PTH1R, PTHR, PTHR1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.76Å
Relevant EMDB volumes: EMD-34598
Expression systems:
  • Trichoplusia ni
  • Escherichia coli

Quick links

Citations

4 review citations

Roles of NOLC1 in cancers and viral infection.
Zhai et al. (2023)
3 more

3 mentions without citation

OsSYL2AA , an allele identified by gene-based association, increases style length in rice (Oryza sativa L.).
Dang et al. (2020)
2 more