› 8hgp

Electron Microscopy
4.53Å resolution

The EREG-bound EGFR/HER2 ectodomain complex

Released:
DOI: 10.2210/pdb8hgp/pdb
PDB entry 8hgp coloured by chain, front view.
PDB entry 8hgp coloured by chain, side view.
PDB entry 8hgp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of the EGFR/HER2 heterodimer.
Bai X, Sun P, Wang X, Long C, Liao S, Dang S, Zhuang S, Du Y, Zhang X, Li N, He K, Zhang Z
OpenAccess logo Cell Discov 9 18 (2023)
PMID: 36781849
Related structures: EMD-34745

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-127218 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Receptor tyrosine-protein kinase erbB-2 Chain: B
Molecule details ›
Chain: B
Length: 745 amino acids
Theoretical weight: 82.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04626 (Residues: 1-693; Coverage: 54%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL
Sequence domains:
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 736 amino acids
Theoretical weight: 81.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00533 (Residues: 1-683; Coverage: 56%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Epiregulin Chain: C
Molecule details ›
Chain: C
Length: 49 amino acids
Theoretical weight: 5.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14944 (Residues: 60-108; Coverage: 35%)
Gene name: EREG

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.53Å
Relevant EMDB volumes: EMD-34745
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

3 review citations

Emerging Targets for Systemic Treatment of Gastric Cancer: HER2 and Beyond.
Kim IH. (2024)
2 more