› 8hhp

X-ray diffraction
2.45Å resolution

Crystal structure of PPARg-LBD complexed with three partial agonists, one nTZDpa and two LT175

Released:
DOI: 10.2210/pdb8hhp/pdb
PDB entry 8hhp coloured by chain, front view.
PDB entry 8hhp coloured by chain, side view.
PDB entry 8hhp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Covalent Modifier Discovery Using Hydrogen/Deuterium Exchange-Mass Spectrometry.
Kojima H, Yanagi R, Higuchi E, Yoshizawa M, Shimodaira T, Kumagai M, Kyoya T, Sekine M, Egawa D, Ohashi N, Ishida H, Yamamoto K, Itoh T
J Med Chem 66 4827-4839 (2023)
PMID: 36994595

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 232-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

2 bound ligands:
Ligand NZA 1 x NZA
Ligand LRG 2 x LRG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P43212
Unit cell:
a: 60.5Å b: 60.5Å c: 162.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.214 0.286
Expression system: Escherichia coli

Quick links