› 8hip

Electron Microscopy
2.77Å resolution

dsRNA transporter

Released:
DOI: 10.2210/pdb8hip/pdb
PDB entry 8hip coloured by chain, front view.
PDB entry 8hip coloured by chain, side view.
PDB entry 8hip coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into double-stranded RNA recognition and transport by SID-1.
Zhang J, Zhan C, Fan J, Wu D, Zhang R, Wu D, Chen X, Lu Y, Li M, Lin M, Gong J, Jiang D
Nat Struct Mol Biol (2024)
PMID: 38664565
Related structures: EMD-34825

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Systemic RNA interference defective protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 776 amino acids
Theoretical weight: 88.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9GZC8 (Residues: 1-776; Coverage: 100%)
Gene names: C04F5.1, rde-7, rsd-8, sid-1
Sequence domains: dsRNA-gated channel SID-1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand 6OU 4 x 6OU
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.77Å
Relevant EMDB volumes: EMD-34825
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain.
Navratna et al. (2024)