8hj0

Electron Microscopy
3.12Å resolution

GPR21(m5) and G15 complex

Released:
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of orphan GPR21 signaling complexes.
OpenAccess logo Nat Commun 14 216 (2023)
PMID: 36639690
Related structures: EMD-33482

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-273963 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 28.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Nb35 Chain: N
Probable G-protein coupled receptor 21 Chain: R

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-33482
Expression systems:
  • Escherichia coli
  • Trichoplusia ni
  • Spodoptera frugiperda