› 8hkk

Electron Microscopy
2.84Å resolution

ion channel

Released:
DOI: 10.2210/pdb8hkk/pdb
PDB entry 8hkk coloured by chain, front view.
PDB entry 8hkk coloured by chain, side view.
PDB entry 8hkk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of human Slo2.2 channel gating and modulation.
Zhang J, Liu S, Fan J, Yan R, Huang B, Zhou F, Yuan T, Gong J, Huang Z, Jiang D
Cell Rep 42 112858 (2023)
PMID: 37494189
Related structures: EMD-34853

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel subfamily T member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1235 amino acids
Theoretical weight: 139.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5JUK3 (Residues: 23-30, 31-41, 42-49, 50-60, 61-65, 66-1033, 1034-1230; Coverage: 97%)
  • Best match: Q5JUK3-3 (Residues: 1-1235)
Gene names: KCNT1, KIAA1422
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand NA 1 x NA
Ligand K 18 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.84Å
Relevant EMDB volumes: EMD-34853
Expression system: Homo sapiens

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