› 8hmx

X-ray diffraction
1.7Å resolution

WDR5 in complex with histone H3Q5his peptide

Released:
DOI: 10.2210/pdb8hmx/pdb
Model geometry
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PDB entry 8hmx coloured by chain, front view.
PDB entry 8hmx coloured by chain, side view.
PDB entry 8hmx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Li HT, Zhao S, Wang HF

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158475 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 33.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P61964 (Residues: 31-334; Coverage: 91%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Histone H3.1 Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 605 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-6; Coverage: 4%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL02U1
Spacegroup: C2
Unit cell:
a: 113.187Å b: 46.857Å c: 65.297Å
α: 90° β: 112.58° γ: 90°
R-values:
R R work R free
0.17 0.168 0.193
Expression systems:
  • Escherichia coli 'BL21-Gold(DE3)pLysS AG'
  • Not provided

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